IgA nephropathy associated with polycythaemia vera: accelerated course.

Key words: crescentic glomerulonephritis; IgA nephro-attacks and urolithiasis from the age of 27 years, along pathy; platelet aggregation; polycythaemia vera with mild proteinuria and haematuria and mild polycy-thaemia 5 years before admission, blood values were haematocrit (Htc) 52%, white blood cell count 13 000/ml, red blood cell (RBC) count 5 600 000/ml, Introduction and platelet count 434 000/ml. There was no family history of hypertension; however, his father also had gout. Although cases of erythrocytosis with concomitant On admission, the patient was afebrile, but the skin glomerulonephritis (GN) have occasionally been on his face had a reddish hue. There was considerable reported, there are few reports regarding polycythae-eczema around the nose, cheeks, and forehead. The mia vera. Polycythaemia vera is a myeloproliferative optic fundi showed retinal haemorrhage compatible disorder resulting from clonal expansion of a trans-with stage III hypertension and stage II arterioloscler-formed haematopoietic stem cell associated with prominent overproduction of erythrocytes, and to a lesser otic retinopathy by Scheie's classification. Cardiac aus-extent expansion of granulocytic and megakaryocytic cultation revealed accentuated second and fourth heart elements. Previous reports presented three cases of sounds. There was neither splenomegaly nor abdom-polycythaemia vera associated with diffuse mesangiop-inal bruit. Both lower extremities had pruritus and the roliferative GN [1 ], and one case associated with ankles were swollen with tenderness. Henoch–Schö nlein purpura nephritis [2]. None of Patient 2, a 51-year-old male with a prior history of these cases was examined by immunofluorescence (IF) polycythaemia vera was referred to our department in or electron-microscopy (EM). We report on two September 1983 for the evaluation of intense pro-patients with concomitant polycythaemia vera and teinuria and haematuria. He had a 10-year history of immunoglobulin-A nephropathy (IgA-N) with simul-bilateral pruritic legs and a 6-year history of a floating taneous aggravation of proteinuria and erythrocytosis. sensation with some episodes of fainting and dysbasia. Renal biopsy specimens of both patients showed active At 47 he was hospitalized with cerebral infarction, and crescentic GN with mesangial proliferation accompan-polycythaemia vera with mild proteinuria was simul-ied by mesangial predominant depositions of IgA. EM taneously diagnosed. However, the treatment with revealed aggregated platelet adhesion to the capillary busulfan and phlebotomy did not start until the next walls of the glomeruli. The possible pathogenesis for year when he began to complain of headaches, nausea, the simultaneous aggravation is discussed. vomiting, and right facial palsy. He had been normot-ensive and among his relatives, only his …